Cluster Randomized Clinical Trials: Ethics and Science


Cluster Randomized Clinical Trials


On March 29, 2017, Edward Liechty, MD gave a presentation on the unique ethical issues that can arise from cluster randomized clinical trials. The video of the presenation can be accessed with the link above. The presenation lasts approximately 37 minutes and is followed by approximately 8 minutes of discussion.

Additional Resources:

Edwards, S. J. L., Braunholtz, D. A., Lilford, R. J., & Stevens, A. J. (1999). Ethical issues in the design and conduct of cluster randomised controlled trials. BMJ?: British Medical Journal, 318(7195), 1407–1409.

Hutton, J. L. (2001). Are distinctive ethical principles required for cluster randomized controlled trials?. Statistics in medicine, 20(3), 473-488.

Osrin, D., Azad, K., Fernandez, A., Manandhar, D. S., Mwansambo, C. W., Tripathy, P., & Costello, A. M. (2009). Ethical challenges in cluster randomized controlled trials: experiences from public health interventions in Africa and Asia. Bulletin of the World Health Organization, 87(10), 772–779.

Weijer, C., Grimshaw, J. M., Taljaard, M., Binik, A., Boruch, R., Brehaut, J. C., ... Zwarenstein, M. (2011). Ethical issues posed by cluster randomized trials in health research. Trials, 12, 100.

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