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Research Ethics

International Health Research

Current Projects

  • The Indiana University-Moi University Academic Research Ethics Partnership, Funder: NIH-Fogarty International Center, PI: Eric M. Meslin

Completed Projects

  • Building a Joint International IRB for Moi University and Indiana University, Funder: NIH- Fogarty International Center, PI: Eric M. Meslin
  • Needs Assessment for Implementing the Indiana University/Moi University [Kenya] “Memorandum of Understanding in Research Ethics”, Funder: International Development Fund, Indiana University, PI: Eric M. Meslin

Publications

  • Ndebele P, Wassenaar D, Benatar S, Fleischer T, Kruger M, Adebamowo C, Kass N, Meslin EM, Hyder. A  Research Ethics capacity building in Sub-Saharan Africa: A review of NIH Fogarty funded programs 2000-2012. Journal of Empirical Research in Human Research Ethics (in press)
  • Fix J, Odell Sina B, Meslin EM, Goodman K, Upshur R.  Bibliometric analysis of the trainee scholarship of the Fogarty International Center’s International Research Ethics Education and Curriculum Development Award, Journal of Empirical Research in Human Research Ethics 2013; 8:75-81. 
  • Meslin EM, Were E, Ayuku D. Taking Stock of the Ethical Foundations of International Health Research: Pragmatic Lessons from the IU-Moi Academic Research Ethics Partnership. Journal of General Internal Medicine  (2013)  28:639-645 DOI:  10.1007/s11606-013-2456-7 
  • Pappas PK, Gakinya BN, Martino S, Baliddawa JB, Bryany KJ, Meslin EM, Sidle, JE.  Ethical issues in a Stage 1 cognitive-behavioral therapy feasibility study and trial to reduce alcohol use among HIV-infected outpatients in western Kenya.  J Empir Res Hum Res Ethics. 2012 Jul;7(3):29-37. PMID: 22850141
  • Thompson, RT, Meslin EM, Braitstein PAK, Nyandiko WM, Ayaya SO, Vreeman RC.  The Vulnerabilities of Orphaned Children Participating in Research:  A Critical Review and Factors for Consideration for Participation in Biomedical and Behavioral Research.  J. Empir Res Hum Res Ethics.  2012 7;4:56-66. 
  • Meslin EM. Achieving global justice in health through global research ethics: supplementing Macklin’s “top-down” approach with one from the “ground up”. In Green RM, Donovan A, Jauss SA, Editors. Global bioethics: issues of conscience for the Twenty-first Century. New York: Oxford University Press; 2009. P. 163-77.
  • Were MC, Meslin EM. Ethics of implementing Electronic Health Records in developing countries: Points to Consider. AMIA Annu Symp Proc. 2011;2011:1499-505. Epub 2011 Oct 22. PubMed PMID: 22195214; PubMed Central PMCID: PMC3243215.
  • Kimmelman J, Weijer C, Meslin EM, The Helsinki Discords: FDA, Ethics, and International Drug Trials, The Lancet 373(9657): 13-14, January 2009 doi:10.1016/S0140-6736(08)61936-4
  • Meslin EM, Were E, Ayuku D. Some Experience Developing a Joint IRB between Moi University (Kenya) and Indiana University (USA). Open Peer Commentary, American Journal of Bioethics.

Study Reports

  • Meslin, EM; Sidle, JE; Wools-Kaloustian, K; Were, E; Salmon, K; Chuani, C. International Research Ethics: A Needs Assessment of Research Ethics Capacity. Volume I: Final Report.  Indiana University Center for Bioethics. June, 2005. http://hdl.handle.net/1805/639
  • Meslin, EM; Sidle, JE; Wools-Kaloustian, K; Were, E; Salmon, K; Chuani, C. International Research Ethics: A Needs Assessment of Research Ethics Capacity. Volume II: The Responses.  Indiana University Center for Bioethics. June, 2005.http://hdl.handle.net/1805/639

Translational Science

Current Projects

  • Indiana Clinical and Translational Science Institute. Funder: NIH-NCRR. Co-Investigators, Investigators: Eric M. Meslin, Kimberly A. Quaid, Peter H. Schwartz

Publications

  • Meslin EM and Schwartz PH. To be or not to be – a research subject. Kushner TK, Editor. Surviving Health Care: A Manual for Patients and Their Families. Cambridge [England]: Cambridge University Press, 2010. Pp. 142-162. 
  • Meslin EM, Blasimme A, Cambon-Thomsen A, Mapping the Science Policy ‘Valley of Death’ Clinical and Translational Medicine. 2013, 2:14. DOI: 10.1186/10.1186/2001-1326-2-14
  • Del Priore G, Saso W, Meslin EM, Tzakis A, Brännström M, Clarke A, Vianna R, Sawyer R, Smith RJ.  Uterine transplantation--a real possibility? The Indianapolis consensus. Hum Reprod. 2013 Feb;28(2):288-91. doi: 10.1093/humrep/des406. Epub 2012 Nov 30.
  • Kaye J, Meslin EM, Knoppers BK, Juengst ET,  Deschênes M, Cambon-Thomsen A, Chalmers DC, Vries J,  Edwards E, Hoppe N, Kent A, Adebamowo C, Marshall P, Kato K.  ELSI 2.0: A New International Collaboratory for Genomics and Society Research. Science  2012; 36:673-4
  • Haas DM, Renbarger JL, Denne S, Ahmed MS, Easterling T, Feibus K, Meslin EM, Koren G, Zajicek A, Snodgrass WR, Flockhart DA.  Summary of Proceedings of the First International Conference for Individualized Pharmacotherapy in Pregnancy, Clinical and Translational Science (2009); 2:11
  • Caulfield T, McGuire AL, Cho M, Buchanan J, Burgess MM, Danilczyk U, Diaz CM,, Fryer-Edwards K, Green SK, Hodosh MA, Juengst ET, Kaye J, Kedes L , Knoppers BM, Lemmens T,  McInnes RR, Meslin EM, Murphy JA,  Nussbaum RL, Otlowski M, Pullman D, Ray PN, Sugarman J, Timmons M . Research Ethics Recommendations for Whole Genome Research: Consensus Statement. PLoS Biol,  6 (March, 2008); 6(3):e73. doi:101371/journal.pbio.0060073

Study Reports

  • Meslin EM, Gaffney MM, Quaid KA, Schwartz PH, Pitt AR, Rager JB. Final summary report: Review of Merck-Regenstrief partnership. Indianapolis: Indiana University Center for Bioethics. Fall 2014. http://hdl.handle.net/1805/6044
  • Survey Research Center at IUPUI. Public attitudes regarding genetic research: survey methods and findings. Indianapolis: Indiana University-Purdue University, Indianapolis. April 2009.http://hdl.handle.net/1805/1959

Biobanks and Pharmacogenomics

Publications

  • Caulfield T, Ogbogu U, Burningham S, Hyde-Lay R, Joly Y, Isasi R, Borry P, Kaye J, McGuire A, Otlowski M, Fullerton M , Meslin EM, Critchley C, Wallace W, Denburg J, Sears M, Gottweis H, Illes J, Pullman D, Scott C, Kato K, Master Z, Ries N.  The Commercialization of Biobanks: Scoping the Policy Issues Journal of Law and the Biosciences, 2014 94-110 doi:1093/jib/lst004
  • Meslin EM. The value of using top-down and bottom-up approaches for building trust and transparency in biobanking. Public Health Genomics. 2010;13(4):207-14. 2010 Apr 15. PubMed Central PMCID: PMC2865393.
  • Meslin EM, Garba I. Biobanking and public health: is a human rights approach the tie that binds? Hum Genet. 2011 Jul 15. PubMed PMID: 21761137.
  • Siede LV Meslin EM. La ciencia de los biobancos, ¿un derecho o un privilege? Hacia un Nuevo contrato social [The science of biobanks, a right or privilege? Towards a New Social Contract] in:  Biotecnologías e Innocacion:  el compromiso social de la ciensa edited by Elizabeth Hodson de Jaramillo, Teodor Zamudilo.  Bogata, Columbia:  Pontificia Universidada Javeriana.  2013:  252-265.
  • Haas DM, Renbarger JL, Meslin EM, Drabiak K, Flockhart D. Patient attitudes toward genotyping in an urban women's health clinic. Obstet Gynecol 2008;112:1023-8.
  • Sly PD, Eskenazi B, Pronczuk J, Sram R, Diaz-Barriga F, Gonzalez Machin D, Surdu S, Carpenter DO, Meslin EM, Ethical Issues in measuring biomarkers in children’s environmental health. Environmental Health Perspectives 2009;117:1185–1190 doi:10.1289/ehp.0800480 available via http://dx.doi.org/ [Online 6 May 2009
  • Schwartz PH. 2009 Walter C. Randall Lecture in Bioethics. Autonomy and consent in biobanks. Physiologist. 2010 Feb;53(1):1, 3-7.
  • Meslin EM, Quaid, KA. Ethical Issues in the Storage, Collection and Research Use of Human Biological Materials Journal of Laboratory and Clinical Medicine November, 2004;144: 229-234
  • Caulfield T, Brown R, Meslin EM, Challenging a Well Established Consent Norm?: One Time Consent for Biobank Research  Journal of International Biotechnology Law (2007) 4; 2: 69-74
  • Evans BJ and Meslin EM., Encouraging Translational Research Through Harmonization of FDA and Common-Rule Informed Consent Requirements for Research with Banked Specimens. Journal of Legal Medicine 2006; 27: 119-166
  • Evans, BJ, Flockhart DA, Meslin EM. Creating incentives for genomics research to improve targeting of therapies. Nature Medicine 2004;10: 1289-91
  • Meslin EM, Ethical issues in constructing and using bio-banks. In Jonathan Beever and Nicolae Morar, Eds. Bioethics, Science, and Public Policy. Purdue University Press, 2013:  123-135

Study Reports

  • Indiana University Center for Bioethics Health Related Philanthropy Study Group. Health related philanthropy: the donation of the body (and the parts thereof). Volume I. Final report of the Health Related Philanthropy Study Group. Indiana University Center for Bioethics. December, 2004. http://hdl.handle.net/1805/638
  • Indiana University Center for Bioethics Health Related Philanthropy Study Group. Health related philanthropy: the donation of the body (and the parts thereof). Volume II. Survey of health related philanthropy in the United States. Indiana University Center for Bioethics. December, 2004. http://hdl.handle.net/1805/638
  • Indiana University Center for Bioethics Health Related Philanthropy Study Group. Health related philanthropy: the donation of the body (and the parts thereof). Volume III.Annotated bibliographies. Indiana University Center for Bioethics. December, 2004.http://hdl.handle.net/1805/638

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